Blar i forfatter "Schmiegelow, Kjeld"

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    • DNA methylation and copy number variation profiling of T-cell lymphoblastic leukemia and lymphoma 

      Haider, Zahra; Landfors, Mattias; Golovleva, Irina; Erlanson, Martin; Schmiegelow, Kjeld; Flægstad, Trond; Kanerva, Jukka; Norén-Nyström, Ulrika; Hultdin, Magnus; Degerman, Sofie (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-28)
      Despite having common overlapping immunophenotypic and morphological features, T-cell lymphoblastic leukemia (T-ALL) and lymphoma (T-LBL) have distinct clinical manifestations, which may represent separate diseases. We investigated and compared the epigenetic and genetic landscape of adult and pediatric T-ALL (<i>n</i> = 77) and T-LBL (<i>n</i> = 15) patient samples by high-resolution genome-wide ...

    • DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia 

      Borssén, Magnus; Nordlund, Jessica; Haider, Zahra; Landfors, Mattias; Larsson, Pär; Kanerva, Jukka; Schmiegelow, Kjeld; Flægstad, Trond; Jónsson, Ólafur Gísli; Frost, Britt-Marie; Palle, Josefine; Forestier, Erik; Heyman, Mats; Hultdin, Magnus; Lönnerholm, Gudmar; Degerman, Sofie (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-05)
      <p><i>Background</i>: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL ...

    • Dna methylation-based subtype prediction for pediatric acute lymphoblastic leukemia 

      Nordlund, Jessica; Bäcklin, Christopher L.; Zachariadis, Vasilios; Cavelier, Lucia; Dahlberg, Johan; Öfverholm, Ingegerd; Barbany, Gisela; Nordgren, Ann; Overnäs, Elin; Abrahamsson, Jonas; Flægstad, Trond; Heyman, Mats M.; Jónsson, Ólafur G.; Kanerva, Jukka; Larsson, Rolf; Palle, Josefine; Schmiegelow, Kjeld; Gustafsson, Mats G.; Lönnerholm, Gudmar; Forestier, Erik; Syvänen, Ann-Christine (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-17)
      Background: We present a method that utilizes DNA methylation profiling for prediction of the cytogenetic subtypes of acute lymphoblastic leukemia (ALL) cells from pediatric ALL patients. The primary aim of our study was to improve risk stratification of ALL patients into treatment groups using DNA methylation as a complement to current diagnostic methods. A secondary aim was to gain insight into ...

    • Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia 

      Nordlund, Jessica; Bäcklin, Christopher L.; Wahlberg, Per; Busche, Stephan; Berglund, Eva C.; Eloranta, Maija-Leena; Flægstad, Trond; Forestier, Erik; Frost, Britt-Marie; Harila-Saari, Arja; Heyman, Mats; Jonsson, Olafur G.; Larsson, Rolf; Palle, Josefine; Rönnblom, Lars; Schmiegelow, Kjeld; Sinnett, Daniel; Söderhäll, Stefan; Pastinen, Tomi; Gustafsson, Mats G.; Lönnerholm, Gudmar; Syvänen, Ann-Christine (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-09-24)
      Background: Although aberrant DNA methylation has been observed previously in acute lymphoblastic leukemia (ALL), the patterns of differential methylation have not been comprehensively determined in all subtypes of ALL on a genome-wide scale. The relationship between DNA methylation, cytogenetic background, drug resistance and relapse in ALL is poorly understood.<p> <p>Results: We surveyed the ...

    • An integrated transcriptome analysis in T-cell acute lymphoblastic leukemia links DNA methylation subgroups to dysregulated TAL1 and ANTP homeobox gene expression 

      Haider, Zahra; larsson, Pär; Landfors, Mattias; Kohn, Linda; Schmiegelow, Kjeld; Flægstad, Trond; Kanerva, Jukka; Heyman, Mats; Hultdin, Magnus; Degerman, Sofie (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-21)
      Classification of pediatric T-cell acute lymphoblastic leukemia (T-ALL) patients into CIMP (CpG Island Methylator Phenotype) subgroups has the potential to improve current risk stratification. To investigate the biology behind these CIMP subgroups, diagnostic samples from Nordic pediatric T-ALL patients were characterized by genome-wide methylation arrays, followed by targeted exome sequencing, ...

    • Multimodal classification of molecular subtypes in pediatric acute lymphoblastic leukemia 

      Krali, Olga; Marincevic-Zuniga, Yanara; Arvidsson, Gustav; Enblad, Anna Pia; Lundmark, Anders; Sayyab, Shumaila; Zachariadis, Vasilios; Heinäniemi, Merja; Suhonen, Janne; Oksa, Laura; Vepsäläinen, Kaisa; Öfverholm, Ingegerd; Barbany, Gisela; Nordgren, Ann; Lilljebjörn, Henrik; Fioretos, Thoas; Madsen, Hans O.; Marquart, Hanne Vibeke; Flægstad, Trond; Forestier, Erik; Jónsson, Ólafur G.; Kanerva, Jukka; Lohi, Olli; Norén-Nyström, Ulrika; Schmiegelow, Kjeld; Harila, Arja; Heyman, Mats; Lönnerholm, Gudmar; Syvänen, Ann-Christine; Nordlund, Jessica (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-08)
      Genomic analyses have redefined the molecular subgrouping of pediatric acute lymphoblastic leukemia (ALL). Molecular subgroups guide risk-stratification and targeted therapies, but outcomes of recently identified subtypes are often unclear, owing to limited cases with comprehensive profiling and cross-protocol studies. We developed a machine learning tool (ALLIUM) for the molecular subclassification ...